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In rodents and perhaps all metazoans, dietary Met is available in vast excess over what is needed for incorporation into protein and to support the Met-cycle [118]

Available from: Liao C, Liang X, Zhang X, Li Y (2023) The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: a systematic review and meta-analysis

doi: 10.1136/gutjnl-2020-323071

Interestingly, these incretin-sensitising effects of metformin appear to be mediated by a peroxisome proliferator-activated receptor -dependent pathway, as opposed to the more commonly ascribed pathway of metformin action involving AMP-activated protein kinase