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At a 4mg/mL concentration (10mg vial in 2.5mL BAC water), a 12mg weekly dose requires a 3mL injection volume which exceeds the practical limit for a single subcutaneous injection into most sites

A biodegradable microsphere loaded with N-glycosylated recombinant glial cell-derived neurotrophic factor (GDNF) was injected into the rat striatum by stereotaxic surgery two weeks after a unilateral partial nigrostriatal lesion induced by the neurotoxic oxidopamin (that selectively destroys dopaminergic neurons)

E., El-Kadem, A

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