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While less common than injection-site irritation, other typical side effects for sermorelin may include ( 5 ): Itching Trouble swallowing Dizziness Flushing Nausea Headaches Overtiredness Changes in mood Trouble sitting still Headaches and nausea from sermorelin use may be linked to changes in hormone signaling or fluid balance, but they are usually temporary For most men, these side effects are mild, short-lived, and manageable with proper guidance from a provider