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We previously tested whether linagliptin reduces pathophysiologic abnormalities in diastolic and vascular endothelial dysfunction in two translationally relevant rodent models of obesity and insulin resistance, the Zucker Obese (ZO) rat [34] and the WD-fed mouse [35, 42]

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The GIP receptor activation adds metabolic effects that pure GLP-1 agonists do not provide, including potential benefits for bone formation and gut motility that may actually buffer against certain gastrointestinal side effects