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Therefore, proinflammatory cytokines and intracellular proteins are the targets of many treatments for moderate to severe UC, including monoclonal antibodies to TNF- and IL-12/23 receptors, which affect these pathways

doi: 10.1016/j.cytogfr.2013.03.003 523 LidburyBAKitaBLewisDPHaywardSLudlowHHedgerMPet al

NT, not tested