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We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide
At the central level, GLP-1 receptors are expressed in regions of the hypothalamus and brainstem that govern appetite and food-seeking behavior
H.JankowskiW.SaunaZ
But the pattern is uncomfortably familiar: a medicine pitched as the simple solution to a complex problem, rolled out at scale, leaving behind long-term dependence and economic side-effects nobody planned for
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