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The appetite suppression these drugs create makes it difficult to eat enough protein to preserve muscle mass, and roughly 25% of weight lost on GLP-1 drugs comes from lean tissue on average, with some trials reporting up to 40%

The weight-suppression model, a unifying framework proposed in eating-disorder research, links GLP-1 physiology to binge eating across diagnostic categories

Amylin receptors are distinct from incretin receptors and are located in brainstem regions involved in appetite and satiety

According to NEJM STEP trials (2021), 86% of patients on semaglutide achieve at least 5% weight loss , with 50% achieving over 15% weight loss