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Interactions with Benzodiazepines and Other CNS Depressants Inform patients and caregivers that potentially fatal additive effects may occur if hydrocodone bitartrate and acetaminophen tablets are used with benzodiazepines and other CNS depressants, including alcohol (e.g., non-benzodiazepines, sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids), and not to use these concomitantly unless supervised by a healthcare provider (see WARNINGS and PRECAUTIONS, Drug Interactions)

Homozygous individuals with this polymorphism (TT genotype) have a 12% prevalence (89)

Additionally, the safety and tolerability profiles of GLP-1RAs have been well-established

Store unopened/unreconstituted vials in a controlled room temperature environment as per manufacturer recommendations