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However, native amylin presents significant challenges for therapeutic use, including rapid enzymatic degradation, tendency to form pathological amyloid fibrils, and poor bioavailability when administered exogenously

Nat Rev Cancer 16:650662 Ye P, Mimura J, Okada T, Sato H, Liu T, Maruyama A, Ohyama C, Itoh K (2014) Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition

The number of inner cell mass (ICM), trophectoderm (TE), and total cell count (TCC) in the Leo20 group was found to be statistically higher than in the control group