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Cancer Metab 2020), suggesting that targeting serine synthesis will be tumor-selective and may have therapeutic benefits in patients

first it seems to withdraw a proton from Cys58, activating the latter residue for a nucleophilic attack on the substrate

Studies using single-cell RNA-sequencing show that Gipr is expressed in various cell types, including neurons, oligodendrocytes, mesenchymal cells and pericyte and tanycyte mural cells 10,11,12