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High-dose vitamin C, magnesium, and B-vitamins have established clinical use for specific deficiency states and have supportive mechanistic evidence for inflammation

The fact that GLP-1R endocytosis promotes endosomal cAMP signalling but is also ultimately a route to receptor downregulation means that, irrespective of the mechanisms by which biased GLP-1RAs achieve their altered trafficking responses, they are likely to contribute to their overall signalling profiles

Strengthens the skin barrier, making it resilient