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This paper is a clinical trial report showing the first highly successful use of an IGF1R-blocking monoclonal antibody in the treatment of moderate to severe GO

[DOI] [PMC free article] [PubMed] [Google Scholar] 59

To this end, we generated strains in which either Taf12 or Taf12L was expressed from a maltose-regulatable promoter ( P MAL2 ), while TFIID and SAGA specific subunits, Taf11 and Ada2 respectively, were TAP-tagged