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[Abstract] Compared with guinea pigs receiving periocular injections of vehicle (5 mM, 10 L on days 1, 4, 7, 10, and 13 over two weeks), those treated with glutathione oxidized (Glu, 20 mg/mL, 10 L on the same schedule) exhibited a 1.76-fold increase in relative myopia, along with a 1.78-fold increase in axial length (AL)

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Astrocytes also regulate oxidative stress and cytokine production through complex pathways that are still being unraveled

These changes increased intracellular accumulation of ECM proteins and decreased secretion into the extracellular environment, indicating impaired protein trafficking and secretion