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It belongs to a new generation of incretin-based compounds often called triple agonists because of their ability to simultaneously activate three distinct metabolic receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)

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Multiple studies have found that patients receiving cortisone injections often experience worse outcomes at 6 and 12 months compared to those who received placebo injections or physical therapy alone