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The ubiquitous presence of glutathione in eukaryotic cells can serve as a signalling virulence switch for some pathogenic bacteria providing a cue that they have reached a favourable host environment (1, 2)
Washout approach (more common): Administer final Wegovy dose Wait 7 to 10 days (approximately 1.5 half-lives) Start Zepbound 2.5 mg Rationale: minimizes overlapping GLP-1 receptor activation, reduces nausea risk Overlap approach (less common, used when continuous appetite suppression is critical): Administer final Wegovy dose Start Zepbound 2.5 mg 3 to 4 days later Rationale: prevents gap in therapeutic effect during washout Risk: higher nausea and GI side effect burden during overlap window Most providers use washout
(September 2019)
Glutathione covalently bound to proteins remains in the pellet post-extraction
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