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However, tryptophan aminotransferases (TAA) are non-specific, and some authors have demonstrated that they work with other aromatic amino acids (phenylalanine, tyrosine, and tryptophan) and others such as leucine, alanine, methionine, and glycine (Kittell et al., 1989

Beyond its direct impact, CB-839, when combined with immunotherapy, has been shown to inhibit the clonal expansion and activation of CD8+ T cells in NSCLC, thereby counteracting the adverse effects associated with PD-1 immunotherapy (89)

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