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Frailty was associated with greater disability (OR: 5.9[3.9-9.1]), cognitive impairment (OR: 1.8[1.0-3.1]), depression (OR: 2.2[1.4-3.5]) and poorer physical (OR: 5.1[2.6-11.2]) and mental quality of life (OR: 1.7[1.1-2.5]) at 3 months

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It acts on the hypothalamus, the brainstem areas involving appetite regulation, reducing the appetite, slowing gastric emptying, but it also hits the reward centers of the brainnucleus accumbens, ventral tegmental area [VTA]influencing reward-driven behaviors