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& Gomez, E

We previously demonstrated that melanocytes obtained from normally pigmented vitiligo skin show cellular and molecular alterations characterized by constitutive activation of antioxidant enzymes 1 and defects in mitochondrial metabolism reflected in altered expression and activity of complex I, increased generation of reactive oxygen species (ROS), low ATP production, and modified expression of some glycolytic enzymes 2

With severe Cu deficiency, the number and ability of neutrophils to generate O 2 and kill absorbed microorganisms, T-cell proliferation and IL-2 production decrease (96)

doi:10.1002/cld.865 [PubMed] 115