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10.1053/j.gastro.2012.06.031 Gastroenterology 133 WaldeckerM.KautenburgerT.DaumannH.BuschC.SchrenkD

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SAFETY AND TOLERABILITY The safety profile of semaglutide in ESSENCE was consistent with its known profile from T2DM and obesity trials [10,12]

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Tirzepatide, as a dual GLP-1/GIP agonist, may have different gastric effects compared to pure GLP-1 agonists, though evidence remains limited [52]

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