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By prioritizing patient education and improving counseling for patients and prescribers on dose titration, product switching, and management of expected gastrointestinal effects, alongside clear prescribing guidance and poison center recommendations, the healthcare community can help ensure that the benefits of GLP-1 RAs are maximized while minimizing adverse outcomes

The increase in ROS or RNS levels involves a concomitant increase of proinflammatory cytokines and the activation of NF-, which in turn activates the hepatic stellate cells, the subsequent fibrosis, and damage to the DNA [12,64], with a failure in the synthesis of exogenous antioxidants [12]

Pharmacol Rep (2016) 68(2):44350

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