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Longitudinal studies in spontaneously hypertensive stroke-prone have demonstrated that gut dysbiosis precedes the onset of hypertension and is marked by shifts in bacterial community structure and altered tryptophan-kynurenine metabolism, implicating microbial pathways in the early development of hypertension and related neurovascular complications (Shi et al., 2022)

Therefore, glucose metabolism disorders in PD have been studied in more detail [13]

In large lesions shave or incisional, in small lesions, punch or excisional biopsy can be adequate depending on the suspicion

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