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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

10.1111/1467-9280.00412 [DOI] [PubMed] [Google Scholar] Sallaberry C, Nunes F, Costa MS, Fioreze GT, Ardais AP, Botton PHS et al (2013) Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats

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