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Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect ()

Proce Nat Acad Sci USA 118(39):e2110476118 Samson AL, Zhang Y, Geoghegan ND et al (2020) MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

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Amat, S., Alexander Trevor, W., Holman Devin, B., Schwinghamer, T