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The textbooks describe a clear hierarchy of approaches: Steps that begin with general dental care: Prompt biopsy of any suspicious pigmented oral lesion, with histopathological examination and immunohistochemistry (S-100, HMB-45, SOX10, MART-1) to confirm the diagnosis

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However, more important is the practical evidence from a considerable number of the studies, particularly in gastrointestinal research, that intragastric administration or per os administration in drinking water, is equally effective as injections of the supplement administered to rodents, which has been performed in the majority of studies on BPC 157