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Skipping the titration phase significantly reduces tolerability

Nature (2012) 483:3504.10.1038/nature10798 Summary Keywords enteroendocrine, appetite, glucagon-like peptide-1, peptide YY, macronutrient Citation Spreckley E and Murphy KG (2015) The L-Cell in Nutritional Sensing and the Regulation of Appetite

For compound treatment, 96-well plates were seeded with 50,000 cells and allowed to adhere for 6 h in complete media containing charcoal-stripped serum