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The latter effect is the result of the reduced ability for platelets to adhere to exposed sub-endothelial extracellular matrix collagen which is required for their activation

Doxepin is converted to the active metabolite desmethyldoxepin by N -demethylation and to other inactive metabolites in liver (Ziegler et al., 1978), and CYP2D6 and CYP2C19 are the main enzymes involved in this metabolism, with CYP1A2 and CYP2C9 involved to a lesser extent (Kirchheiner et al., 2002

But you still need to eat in a calorie deficit for weight loss, choose nutrient-dense whole foods most of the time, get regular physical activity including both cardio and strength training, get adequate sleep since poor sleep disrupts appetite hormones, manage stress as chronic stress elevates cortisol and promotes fat storage, and address emotional or behavioral eating patterns