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Biol Psychiatry 73(5):454463 Hastings JA, Morris MJ, Lambert G, Lambert E, Esler M (2004) NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro
This was because hydroxocobalamin produced by bacteria was changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures (because cyanide is naturally present in activated charcoal)
Studies have found 12-58% of supplements in related categories contain contaminants, with 30% containing incorrect amino acid sequences and 65% exceeding endotoxin safety thresholds
Reconstituted solutions should be refrigerated (28C) and used within a defined window per laboratory SOPs
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