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Description

In a phase 2b trial, tirzepatide treatment was associated in a dose-dependent manner with decreased levels of apolipoprotein (apo) B, apoC-III, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles, suggesting a shift towards a less atherogenic lipoprotein profile [77]

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The AcM enzyme used in this study is same as the one previously described [28] and marketed under the trade name of Balancius TM (dsm-firmenich animal nutrition and health, Wurmisweg, 576, 4303, Kaiseraugst, Switzerland).The gene coding for this AcM is from the fungus Acremonium alcalophilum (strain 114.92), and its activity is expressed in MUR units LSU(F)

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