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FDA-approved indications are clearly distinguished from off-label or investigational uses, such as polycystic ovary syndrome (PCOS) or non-alcoholic steatohepatitis (NASH)

4 Trauma and post-inflammatory pigmentation Any repeated micro-trauma to a specific point on the lip (a habitual lip-biting spot, friction from a tooth, a healed cold sore, an old burn from hot food or drinks) can trigger localized post-inflammatory hyperpigmentation that stabilizes into a melanotic macule

Without adequate copper delivery to these enzymes, collagen forms but does not properly crosslink, producing weaker tissue

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