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Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

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Vitamin B12 injections have essentially no negative side effects, except for extremely rare cases in which patients are allergic or sensitive to the injection

Vitamin B12 shots are typically prescribed for individuals with a diagnosed vitamin B12 deficiency