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Conclusions In this study, we developed and validated a novel, label-free HPLC-MS/MS method for the comprehensive, simultaneous quantification of 21 key metabolites involved in glutathione and sulfur metabolism

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A major output of the NRF2 transcriptional program is involved in redox regulation in which sulfur atoms play a central role, such as glutathione synthesis and reduction, thioredoxin synthesis and reduction, and cystine uptake (Yamamoto et al

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