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Potential Benefits & Side Effects Observations from preclinical and clinical literature on IGF-1 and its analogs

The anti-ferroptotic action of Fer-1 primarily arises from its capacity to scavenge alkoxyl radicals and reactive species generated by ferrous iron in lipid hydroperoxides

In addition, we found here that inhibition of either the mitochondrial (IDH2) or cytosolic (IDH1 and ME1) NADPH-producing enzymes diminishes ER stress, and we have found previously that inhibition of the pentose phosphate pathway does likewise (Tyra et al., 2012)

While the body produces glutathione naturally, levels can decline due to aging, stress, poor nutrition, and environmental factors