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MAO-A is more dominant in the heart, platelets, gut, and certain neurons, while MAO-B is prevalent in astrocytes and specific brain regions, as well as in the heart, intestines, kidneys, and blood vessels.[ref][ref][ref] Variants in the MAOA gene sometimes called the warrior gene can affect neurotransmitter levels and have been linked to changes in mood, aggressiveness, and response to antidepressants

In summary we hypothesised that changes in the neurochemical properties of two key regions of fronto-striatal circuitry relevant to compulsivity the SMA and ACC will be more evident in OCD and probably expressed in the healthy population as a function of the transdiagnostic dimension of compulsivity

It is deeply involved in immune system regulation

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