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The dual mechanism is the most plausible explanation for the larger average effect, but "plausible explanation for a group difference" is a much weaker claim than "will work better for you." Response varied enormously within both arms of SURMOUNT-5, which is why the trial reported the proportion of participants hitting each threshold rather than a single expected result

GLP-1 drugs have become widely used, but they have also been expensive and hard to afford, which is part of what these new programs aim to address

Do not ignore severe or persistent symptoms: seek medical attention

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