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If there is no response to a 2-3 month trial of regular PDE5 inhibitor treatment, consider referring the man to a medically robust, caring provider for consideration of intracavernosal injection treatment

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When applied to the skin, it may also cause mild skin or eye irritation ( Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages ( However, no studies have explored this potentially problematic combination yet

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