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Grant I, Atkinson JH, Hesselink JR, Kennedy CJ, Richman DD, Spector SA, et al

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Otherwise, the expression level of the receptors for GLP-1 and/or GIP (hereafter, GLP-1R and GIPR, respectively) in pancreatic -cells is a critical factor in determining the action of the incretin hormones [20]

According to FDA guidance, GLP-1 medications are not recommended for people who have: Pregnancy, because safety data are limited and pregnancy requires appropriate weight gain and nutrient storage A prior history of pancreatitis, due to a risk of triggering inflammation of the pancreas A history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2), a rare genetic condition linked to thyroid cancer in animal studies A clinician will review your medical history carefully to determine whether these medications are appropriate for you