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Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions

doi: 10.1101/pdb.prot4666 50 WuQ

Epidemiological trends reveal an increasing prevalence of drug-induced neurological disorders worldwide, influenced by expanding pharmaceutical use, polypharmacy, and environmental exposure [137]

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