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Sometimes this issue is fixed simply by optimizing buffers, for instance by increasing salt or detergent concentration, so that the interacting protein no longer binds to the GST only control, but still binds to your GST-fusion protein of interest

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Initially targeted towards Type 2 diabetes, the significant weight loss benefits observed with GLP-1 RAs such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda ) and tirzepatide (Mounjaro) have led to these treatments becoming blockbuster weight management therapies as well as effective diabetes medications