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Owing to incremental therapeutic advances and the advent of new antihyperglycemic medications, obesity treatment and cardiovascular risk management have become essential in establishing the standards of medical care in diabetes ( Current international guidelines recommend GLP-1 RAs with proven cardiovascular benefits for patients with T2D and established cardiovascular disease or risk factors to reduce cardiovascular events ( Conclusion The prominent capacity of subcutaneous and oral semaglutide administration to improve glycemic control and weight management with no key safety concerns represents a major therapeutic advance

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