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Comorbidities CVS is probably not the result of a single pathogenetic mechanism, rather the common final clinical picture (cyclical emesis attacks) of different physiopathological pathways, with different threshold, and many triggers can be able to elicit it (79)

When mature IGF-I lacking any E-peptide extension was expressed virally, it failed to increase muscle mass, whereas the E-peptide-bearing IGF-IA and IGF-IB isoforms drove hypertrophy evidence that, in this system, the E-domain is necessary for the local anabolic effect rather than being an inert appendage

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10.1007/bf01168338 10 BarnaB.FodorJ.HarrachB