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doi: 10.1080/15563650.2020.1788056.) My own view is there will never be a well-done RCT that settles this question, given the imposing costs and logistics required, as well as the relatively few patients who would be eligible

Abbreviations VTS: Vanishing testis syndrome SHs: Sex hormones DHT: Dihydrotestosterone SDS: Standard deviation score IGF-1: Insulin-like growth factor-1 GH: Growth-hormone IGFBPs: Insulin-like growth factor-binding proteins References Houk CP, Hughes IA, Ahmed SF, Lee PA

Multiple test types (HPLC, MS, amino acid analysis) provide more confidence than single-method verification