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Additional ingredients such as berberine and saffron extract have been studied for their roles in metabolic health and appetite perception

Fat cells release inflammatory mediators known as adipokines , including: Leptin Adiponectin Interleukin-6 Tumor necrosis factor-alpha These mediators contribute to: Cartilage degradation Synovial inflammation Osteophyte formation Because of these mechanisms, obesity is considered one of the most important modifiable risk factors for knee osteoarthritis

The mechanisms underlying these effects are likely multifactorial

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