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It's the same stalled healing response being disrupted, over and over again

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369 Advanced glycation end products, which are generated by glucose in a non-enzymatic manner, also promote ROS production and endoplasmic reticulum stress, and then induce insulin suppression via the protein kinase RNA-like endoplasmic reticulum kinase/forkhead box O1 pathway

J Transl Med 18:100 Lin T-N, Cheung W-M, Wu J-S, Chen J-J, Lin H, Chen J-J, Liou J-Y, Shyue S-K, Wu KK (2006) 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury