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Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

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The approval was based on data from the ongoing Phase II PHAROS clinical trial, which is studying the combination in both treatment-nave and previously treated patients with BRAF V600E-mutant metastatic NSCLC

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