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The first pathway involves remethylation catalyzed by the vitamin B 12 -dependent methionine synthase, which captures a methyl group from the folate-dependent one-carbon pool (5-methyltetrahydrofolate)

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Thus, to better understand at which stage GSH is essential in the maintenance of B cells in the adult mouse, we measured Gclc expression and total GSH in TrB from mutant and control mice