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Cuprizone-induced demyelination in animals is accepted for studying multiple sclerosis-related lesions and is characterized by degeneration of oligodendrocytes more than by a direct attack on the myelin sheet (12)

As the respective macrocycles were selected as peptidemRNA fusions via a carboxy-terminal (GS) 3 -linker, each peptides C-terminus appeared likely to tolerate not only FLAG modification but also binding to an anti-FLAG monoclonal antibody (mAb) without compromising the structure of the active macrocyclic region

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