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Melanotan 2 is non-selective, activating MC1R through MC5R, which adds libido enhancement and appetite suppression but also produces more side effects including nausea, spontaneous erections, and higher rates of new mole formation

2 Molecular mechanism of GLP-1RA in the eye Hernndez et al

While cortisol is essential for survival, chronically elevated levels can trigger fat storageespecially around the abdomenincrease hunger signals, and promote insulin resistance