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Whats more, infections, chronic stress, injuries, environmental toxins, genetically modified foods and artificial sweeteners, overuse of antibiotics, and busy schedules with sleep deprivation have driven production to dismal levels as we age

As we age, we do not absorb B12 efficiently from our diet

Morphine reduces PVN Glu neuronal activity via MOR to induce constipation MOR activation has been shown to modulate neuronal function through well-established G protein signaling mechanisms, such as postsynaptic activation of G protein-coupled inwardly rectifying potassium channels, which causes hyperpolarization and inhibition of neurons 29,30,31

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