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For sustained weight loss, pair interventions: nutrition, behavior change, progressive activity, and, where suitable, medications or supplements backed by trials

Conditions such as atrophic gastritis (thinning of the stomach lining), Pernicious anemia (which makes it harder for your body to absorb Vitamin B12), Intestinal diseases such as crohns disease, celiac disease, bacterial growth and immune system disorders such as Graves disease or lupus can lead to Vitamin B12 deficiency in the body

It may also improve fatigue and insomnia

For individuals whose primary challenge is overeating, this represents a significant limitation