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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (, , )

This suggests that the facilitation of neovascularization mediated by HIF signaling has the potential to enhance blood perfusion within injured tissues, thereby potentially mitigating the hypoxic environment experienced by AID patients

Additionally, while we included studies with both cognitive and motor training components, there was substantial variability in task design, exposure time, and assessment tools, making it difficult to determine which specific aspects of VR training contributed most to cognitive and functional improvements